Paramyxovirus Disruption of Interferon Signal Transduction: STATus Report

J Interferon Cytokine Res. 2009 Sep;29(9):531-7. doi: 10.1089/jir.2009.0070.

Abstract

RNA viruses in the paramyxovirus family have evolved a number of strategies to escape host cell surveillance and antiviral responses. One mechanism exploited by a number of viruses in this family is direct targeting of cytokine-inducible transcription regulators in the STAT family. Diverse members of this large virus family effectively suppress STAT signaling by the actions of their V proteins, or the related proteins derived from alternate viral mRNAs. These viral proteins have distinct means of targeting STATs, resulting in a variety of negative effects on STATs and their signal transduction. Recent developments in understanding STAT targeting will be reviewed.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Down-Regulation
  • Humans
  • Immunity, Innate
  • Interferons / immunology*
  • Paramyxoviridae / immunology*
  • Paramyxoviridae / pathogenicity
  • Paramyxoviridae Infections / genetics
  • Paramyxoviridae Infections / immunology*
  • Paramyxoviridae Infections / virology*
  • STAT Transcription Factors / genetics
  • STAT Transcription Factors / metabolism*
  • Signal Transduction
  • Viral Proteins / immunology
  • Viral Proteins / metabolism

Substances

  • STAT Transcription Factors
  • V protein, Paramyxovirus
  • Viral Proteins
  • Interferons