Predictors of interleukin-6 elevation in older adults

J Am Geriatr Soc. 2009 Sep;57(9):1672-7. doi: 10.1111/j.1532-5415.2009.02426.x. Epub 2009 Aug 18.


Objectives: To investigate the characteristics of older adults who develop high interleukin-6 (IL-6) levels at 3-year follow-up.

Design: Population-based study of adults living in Tuscany, Italy.

Setting: Community.

Participants: Adults aged 65 and older and were selected for this study. Of 1,155 baseline participants aged 65 and older, 741 had IL-6 measurements at baseline and 3-year follow-up.

Measurements: The uppermost quartile of IL-6 was used as the threshold for defining high IL-6 (> or =4.18 pg/mL). Serum IL-6 levels were assessed using enzyme immunoassay.

Results: Of the 581 participants with IL-6 levels less than 4.18 pg/mL at baseline, 106 (18.2%) had developed high IL-6 at follow-up. Although women had lower IL-6 levels at baseline than men, the risk of developing high IL-6 did not differ according to sex. High adiposity, defined as a body mass index of 30.0 kg/m(2) or higher (odds ratio (OR)=2.63, 95% confidence interval (CI)=1.40-4.96), and large waist circumference, defined as 102 cm or greater for men and 88 cm or greater for women (OR=2.05, 95% CI=1.24-3.40), were significant predictors of developing high IL-6 at follow-up. Other significant predictors were presence of three or more chronic diseases (OR=3.66, 95% CI=1.54-8.70), higher baseline IL-6 (OR=1.82, 95% CI=1.39-2.38) and higher white blood cell count (OR=1.24, 95% CI=1.06-1.45). Faster walking speed associated with decreased risk of progressing to elevated IL-6 (OR=0.83, 95% CI=0.74-0.92).

Conclusion: Older age, greater adiposity, slower walking speed, higher disease burden, and higher white blood cell count were associated with greater risk of IL-6 elevation over a 3-year period. Future research should target older adults with these characteristics to prevent progression to a proinflammatory state.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aging / immunology*
  • Body Mass Index
  • Chronic Disease / epidemiology
  • Cohort Studies
  • Female
  • Humans
  • Interleukin-6 / blood*
  • Italy
  • Leukocyte Count
  • Longitudinal Studies
  • Male
  • Mobility Limitation
  • Reference Values
  • Risk Factors
  • Sex Factors
  • Statistics as Topic
  • Waist-Hip Ratio


  • Interleukin-6