A centromere map of the X chromosome from trisomies of maternal origin

Ann Hum Genet. 1990 Jan;54(1):39-47. doi: 10.1111/j.1469-1809.1990.tb00359.x.


A centromere map is derived from XXX and XXY trisomies of maternal origin. Preliminary data suggest reduced recombination in the tetrads giving rise to mei I nondisjunction, but an excess of recombination in the pericentric region. As in Drosophila, multichiasmate tetrads may be more at risk of nondisjunction than nullochiasmate tetrads.

MeSH terms

  • Animals
  • Centromere*
  • Chromosomes*
  • Crossing Over, Genetic
  • Drosophila melanogaster
  • Female
  • Humans
  • Mothers*
  • Polymorphism, Restriction Fragment Length*
  • Trisomy*
  • X Chromosome*