Thio FCMA intermediates as strong acyl donors: a general solution to the formation of complex amide bonds

J Am Chem Soc. 2009 Sep 16;131(36):12924-6. doi: 10.1021/ja906005j.


Novel methodology for the formation of amide bonds under neutral conditions is described. Evidence is presented that the active acyl donors are thio FCMA intermediates, generated from the reactions of thioacids with isonitriles.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Amides / chemistry*
  • Molecular Structure
  • Nitriles / chemistry
  • Sulfur Compounds / chemistry


  • Amides
  • Nitriles
  • Sulfur Compounds