Potential therapeutic failure of generic vancomycin in a liver transplant patient with MRSA peritonitis and bacteremia

J Infect. 2009 Oct;59(4):277-80. doi: 10.1016/j.jinf.2009.08.005. Epub 2009 Aug 19.

Abstract

We report a case of generic vancomycin treatment failure in a liver transplant patient with MRSA peritonitis and bacteremia, followed by a rapid sterilization of blood and peritoneal fluid after switching to the branded product. It raises concern about therapeutic equivalence of generic vancomycin.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Bacteremia / drug therapy*
  • Drugs, Generic / therapeutic use
  • Humans
  • Liver Transplantation*
  • Male
  • Methicillin-Resistant Staphylococcus aureus*
  • Middle Aged
  • Peritonitis / drug therapy*
  • Staphylococcal Infections / drug therapy*
  • Treatment Outcome
  • Vancomycin / therapeutic use*

Substances

  • Anti-Bacterial Agents
  • Drugs, Generic
  • Vancomycin