Serum adipsin levels in patients with seasonal allergic rhinitis: preliminary data

Int Immunopharmacol. 2009 Nov;9(12):1460-3. doi: 10.1016/j.intimp.2009.08.004. Epub 2009 Aug 20.


Background: Several studies have outlined a possible relationship between adipokines and respiratory allergic diseases. However, there are no data about a role for adipsin in allergic rhinitis.

Objective: The aim of the study was to evaluate the serum adipsin levels in patients with seasonal allergic rhinitis (SAR), subdivided into two sub-groups: treated or not treated with sublingual immunotherapy (SLIT), and in a group of healthy controls.

Methods: The study included 110 subjects; i) 24 SLIT-treated SAR patients, ii) 62 untreated SAR patients, and iii) 24 normal subjects. All subjects were consecutively evaluated. A skin prick test and blood sampling for assessing serum adipsin levels were performed in all subjects.

Results: Serum adipsin was increased in SAR patients, even though significant only in males. There was also a significant positive association between adipsin and adiponectin.

Conclusion: This preliminary study reports that adipsin serum levels may be increased in some SAR patients, but further functional studies should be performed.

MeSH terms

  • Administration, Sublingual
  • Adolescent
  • Adult
  • Aged
  • Antigens, Plant / immunology*
  • Antigens, Plant / metabolism
  • Cell Count
  • Complement Factor D / immunology
  • Complement Factor D / metabolism
  • Desensitization, Immunologic*
  • Disease Progression
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nasal Obstruction
  • Pollen / metabolism
  • Rhinitis, Allergic, Seasonal / blood*
  • Rhinitis, Allergic, Seasonal / immunology*
  • Rhinitis, Allergic, Seasonal / physiopathology
  • Rhinitis, Allergic, Seasonal / therapy
  • Skin Tests
  • Sneezing


  • Antigens, Plant
  • CFD protein, human
  • Complement Factor D