Uncombable hair syndrome

J Am Acad Dermatol. 2009 Sep;61(3):512-5. doi: 10.1016/j.jaad.2009.01.006.


Uncombable hair syndrome is a relatively rare anomaly of the hair shaft, with less than 100 cases reported to date, that results in a disorganized, unruly hair pattern that is impossible to comb flat. The characteristic longitudinal grooves along the hair shaft, along with the triangular or kidney-shaped cross section allows this condition to be diagnosed microscopically. The majority of cases are inherited in an autosomal-dominant manner with either complete or incomplete penetrance. There is no definitive treatment, and most cases improve with the onset of puberty.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Ectodermal Dysplasia / genetics*
  • Ectodermal Dysplasia / pathology*
  • Female
  • Genes, Dominant
  • Hair / pathology*
  • Hair / ultrastructure
  • Hair Diseases / genetics
  • Hair Diseases / pathology*
  • Hair Preparations
  • Humans
  • Microscopy, Electron


  • Hair Preparations