Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562
- PMID: 19700240
- DOI: 10.1016/j.canlet.2009.07.015
Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562
Abstract
Cucurbitacin B is a natural anti-cancer compound found in Cucurbitaceae. Although the anti-cancer activity of cucurbitacin B in human leukemia cells has been reported, the underlining mechanism is still unclear. To clarify its anti-cancer activity and the mechanism of action, five different leukemia cell lines (CCRF-CEM, K562, MOLT-4, RPMI-8226 and SR) of the National Cancer Institute panel were treated with cucurbitacin B. Leukemia cell growth was inhibited by cucurbitacin B with GI(50) ranged from 15.6 nM to 35.3 nM and the growth inhibition effect was attributable to G2/M phase arrest and apoptosis. Western blotting analysis of cell signaling molecules indicated that cucurbitacin B inhibits STAT3 activation and the Raf/MEK/ERK pathway in the K562 cells.
Crown Copyright 2009. Published by Elsevier Ireland Ltd. All rights reserved.
Comment in
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Response to letter to editor by Dr. Wiart.Cancer Lett. 2013 Jan 1;328(1):189. doi: 10.1016/j.canlet.2012.01.032. Epub 2012 Jan 28. Cancer Lett. 2013. PMID: 22289721 No abstract available.
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The definition and significance of Cucurbitacin B a STAT3 inhibitors.Cancer Lett. 2013 Jan 1;328(1):188. doi: 10.1016/j.canlet.2012.01.033. Epub 2012 Feb 3. Cancer Lett. 2013. PMID: 22306703 No abstract available.
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