Computerized cognitive assessment of mild cognitive impairment in urban African Americans

Am J Alzheimers Dis Other Demen. Oct-Nov 2009;24(5):396-403. doi: 10.1177/1533317509342982. Epub 2009 Aug 21.

Abstract

Few objective cognitive assessment tools have been validated for mild cognitive impairment (MCI) in African Americans despite higher prevalence of disease. This preliminary study evaluated discriminant validity of a computerized cognitive assessment battery for MCI in an urban African American cohort. Twenty-seven participants with MCI and 22 cognitively healthy individuals completed a multidomain battery (Mindstreams, NeuroTrax Corp, New Jersey). Mild cognitive impairment participants performed more poorly than cognitively healthy participants in all domains, with significant differences in memory (P = .003; d = 0.96), executive function (P = .046; d = 0.64), and overall battery performance (P = .041; d = 0.63). Adjustment for intelligence quotient (IQ) yielded significant differences in memory (P < .001; d = 1.34), executive function (P = .007; d = 0.86), attention (P = .014; d = .80), and overall performance (P = .001; d = 1.09). Such a validated battery may help to address an important clinical need in this population.

Publication types

  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Adult
  • African Americans* / statistics & numerical data
  • Aged
  • Cognition Disorders / diagnosis*
  • Cognition Disorders / ethnology
  • Diagnosis, Computer-Assisted / methods*
  • Diagnosis, Computer-Assisted / standards
  • Female
  • Humans
  • Intelligence Tests
  • Male
  • Memory
  • Neuropsychological Tests
  • Prevalence
  • Reproducibility of Results
  • Severity of Illness Index*
  • Software
  • Urban Population* / statistics & numerical data
  • Verbal Learning