Biological properties of a CD4 immunoadhesin

Nature. 1990 Apr 12;344(6267):667-70. doi: 10.1038/344667a0.

Abstract

Molecular fusions of CD4, the receptor for human immunodeficiency virus (HIV), with immunoglobulin (termed CD4 immunoadhesins) possess both the gp120-binding and HIV-blocking properties of recombinant soluble CD4, and certain properties of IgG, notably long plasma half-life and Fc receptor binding. Here we show that a CD4 immunoadhesin can mediate antibody-dependent cell-mediated cytotoxicity (ADCC) towards HIV-infected cells, although, unlike natural anti-gp120 antibodies, it does not allow ADCC towards uninfected CD4-expressing cells that have bound soluble gp120 to the CD4 on their surface. In addition, CD4 immunoadhesin, like natural IgG molecules, is efficiently transferred across the placenta of a primate. These observations have implications for the therapeutic application of CD4 immunoadhesins, particularly in the area of perinatal transmission of HIV infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acquired Immunodeficiency Syndrome / congenital
  • Acquired Immunodeficiency Syndrome / immunology
  • Animals
  • Antibodies, Anti-Idiotypic / immunology*
  • Antibody-Dependent Cell Cytotoxicity / immunology
  • Antigens, CD / immunology*
  • CD4 Immunoadhesins
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / microbiology
  • Female
  • HIV / immunology*
  • HIV Envelope Protein gp120 / immunology
  • Humans
  • Immunity, Maternally-Acquired
  • Immunoglobulin G / immunology*
  • Macaca mulatta
  • Pregnancy
  • Recombinant Proteins

Substances

  • Antibodies, Anti-Idiotypic
  • Antigens, CD
  • CD4 Immunoadhesins
  • HIV Envelope Protein gp120
  • Immunoglobulin G
  • Recombinant Proteins