Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family

Nat Rev Cancer. 2009 Sep;9(9):615-30. doi: 10.1038/nrc2695.


The three homologous members of the p160 SRC family (SRC1, SRC2 and SRC3) mediate the transcriptional functions of nuclear receptors and other transcription factors, and are the most studied of all the transcriptional co-activators. Recent work has indicated that the SRCgenes are subject to amplification and overexpression in various human cancers. Some of the molecular mechanisms responsible for SRC overexpression, along with the mechanisms by which SRCs promote breast and prostate cancer cell proliferation and survival, have been identified, as have the specific contributions of individual SRC family members to spontaneous breast and prostate carcinogenesis in genetically manipulated mouse models. These studies have identified new challenges for cancer research and therapy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Histone Acetyltransferases / physiology*
  • Humans
  • Neoplasms / metabolism*
  • Nuclear Receptor Coactivator 1
  • Nuclear Receptor Coactivator 2 / physiology*
  • Nuclear Receptor Coactivator 3
  • Trans-Activators / physiology*
  • Transcription Factors / physiology*
  • Transcription, Genetic


  • Nuclear Receptor Coactivator 2
  • Trans-Activators
  • Transcription Factors
  • Histone Acetyltransferases
  • NCOA1 protein, human
  • NCOA3 protein, human
  • Ncoa1 protein, mouse
  • Ncoa3 protein, mouse
  • Nuclear Receptor Coactivator 1
  • Nuclear Receptor Coactivator 3