Epidermal growth factor receptor-regulated miR-125a-5p--a metastatic inhibitor of lung cancer

FEBS J. 2009 Oct;276(19):5571-8. doi: 10.1111/j.1742-4658.2009.07238.x. Epub 2009 Aug 21.


Both the epidermal growth factor receptor signaling pathway and microRNA (miRNA) play an important role in lung cancer development and progression. To address the potential role of miRNA in epidermal growth factor receptor signaling, we identified miR-125a-5p as a downstream target, using an miRNA array. We further demonstrated that miR-125a-5p inhibited migration and invasion of lung cancer cells. Moreover, miR-125a-5p regulated the expression of several downstream genes of epidermal growth factor receptor signaling. Importantly, examination of lung cancer samples revealed a significant correlation of miR-125a-5p repression with lung carcinogenesis. Taken together, our results provide compelling evidence that miR-125a-5p, an epidermal growth factor-signaling-regulated miRNA, may function as a metastatic suppressor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Cell Movement / genetics
  • Cell Survival
  • ErbB Receptors / metabolism*
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / metabolism*
  • Lung Neoplasms / secondary
  • MAP Kinase Signaling System
  • MicroRNAs / antagonists & inhibitors
  • MicroRNAs / genetics*
  • Neoplasm Invasiveness / genetics
  • RNA, Antisense / genetics
  • RNA, Neoplasm / genetics*
  • Signal Transduction


  • MIRN125 microRNA, human
  • MicroRNAs
  • RNA, Antisense
  • RNA, Neoplasm
  • ErbB Receptors