Amoxicillin-clavulanic acid-induced linear immunoglobulin A bullous dermatosis: case report and review of the literature

Int J Dermatol. 2009 Sep;48(9):1006-10. doi: 10.1111/j.1365-4632.2009.04104.x.


Background: Linear immunoglobulin A bullous dermatosis (LABD) is an autoimmune subepidermal blistering disease, rarely induced by drugs.

Methods: We describe a case of a 47-year-old man who developed a severe blistering eruption after therapy with amoxicillin-clavulanic acid.

Results: Histopathologic examination and direct immunofluorescence were consistent with a diagnosis of LABD. Therapy with dapsone controlled the disease but, after sun exposure, there was a worsening of the illness.

Conclusion: To our knowledge, this is the first case of amoxicillin-clavulanic acid-induced LABD in an adult.

Publication types

  • Case Reports

MeSH terms

  • Amoxicillin-Potassium Clavulanate Combination / adverse effects*
  • Humans
  • Immunoglobulin A*
  • Male
  • Middle Aged
  • Skin Diseases, Vesiculobullous / chemically induced*
  • Skin Diseases, Vesiculobullous / immunology*


  • Immunoglobulin A
  • Amoxicillin-Potassium Clavulanate Combination