Only two ways to achieve perfection

Cell. 2009 Aug 21;138(4):619-21. doi: 10.1016/j.cell.2009.08.010.


The functional repertoire of a network is determined by its topology. Ma et al. (2009) analyze enzyme networks with three nodes and take a reverse-engineering approach to ask how many core network topologies can establish perfect adaptation, the ability to reset after perturbation. Surprisingly, the answer is just two.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Physiological*
  • Computer Simulation
  • Enzymes / physiology
  • Models, Biological*


  • Enzymes