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. 2009 Nov 10;1297:135-42.
doi: 10.1016/j.brainres.2009.08.051. Epub 2009 Aug 21.

Taste-potentiated Odor Aversion Learning in Rats With Lesions of the Insular Cortex

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Free PMC article

Taste-potentiated Odor Aversion Learning in Rats With Lesions of the Insular Cortex

Jian-You Lin et al. Brain Res. .
Free PMC article

Abstract

The current study assessed the influence of excitotoxic lesions of the insular cortex (IC) on taste-potentiated odor aversion (TPOA) learning. Water-deprived rats initially received a single odor-toxicosis or odor/taste-toxicosis pairing and were subsequently tested, in separate trials, with the odor and the taste stimulus. Indicating TPOA, neurologically intact rats conditioned with the odor/taste compound stimulus acquired significantly stronger odor aversions than normal rats conditioned with the odor stimulus. IC lesions disrupted TPOA, conditioned taste aversion and taste neophobia. The finding that taste did not potentiate odor aversion learning in the IC-lesioned rats provides support for the "within-compound association" analysis but is inconsistent with the "sensory-and-gate" account of TPOA learning.

Figures

Fig. 1
Fig. 1
Digitalized photomicrographs of the insular cortex (IC) from a neurologically intact animal (A) and from a rat with a representative NMDA lesion of the IC (B). The extent of the lesion is outlined with a dashed line. Serial reconstructions (C) of the largest (gray) and smallest (diagonal lines) IC lesions at three coronal levels (+2.28, +1.20, 0.00 mm) anterior to bregma. CPu, caudate putamen; rf, rhinal fissure; S2, secondary somatosensory cortex. The diagrams were modified with permission from Paxinos and Watson (2005).
Fig. 2
Fig. 2
Mean (+SE) intake of the odor stimulus (0.02% orange extract) for the neurologically intact (SHAM) subjects and insular cortex-lesioned (ICX) rats during the odor test trial that followed conditioning with either the odor (O) stimulus or the odor/taste (orange/quinine; OT) compound stimulus.
Fig. 3
Fig. 3
Mean (+SE) intake of the taste stimulus (0.00006 M quinine hydrochloride) for the neurologically intact (SHAM) subjects and insular cortex-lesioned (ICX) rats during the taste test trial conducted after the odor test trial in rats that were conditioned with either the odor (O) stimulus or the odor/taste (orange/quinine; OT) compound stimulus.

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