Homologues of Arabidopsis Microtubule-Associated AIR9 in Trypanosomatid Parasites: Hints on Evolution and Function

Plant Signal Behav. 2007 Jul;2(4):296-9. doi: 10.4161/psb.2.4.4041.

Abstract

AIR9 is an essential microtubule-associated protein from Arabidopsis. Sequence similarity searches indicate homologues of AIR9 in land plants and in excavate protists, including trypanosomatid parasites and Trichomonas. The AIR9-like protein from Trypanosoma brucei was recently detected in the proteome of the trypanosome flagellum, raising the possibility that trypanosomatid AIR9-like proteins also associate with microtubules. Because microtubule functions are essential to the viability of trypanosomatid parasites AIR9-like proteins may be exploited as drug targets without homology in humans. We further discuss the unexpected phylogeny of AIR9-like proteins from plants and protozoans.

Keywords: A9 domain; Excavata; cortical microtubules; flagellum; plant; preprophase band.