Experimental and clinical pharmacokinetics of amitryptiline: comparative analysis

Bull Exp Biol Med. 2009 Apr;147(4):434-7. doi: 10.1007/s10517-009-0520-4.
[Article in English, Russian]


Pharmacokinetics of two amitriptyline tablets, Amitryptiline Nycomed and Amitryptiline, was investigated clinically and experimentally after a single oral dose of 50 mg. A statistically significant correlation between amitryptiline serum concentrations in dogs and healthy humans (r=0.683, p<0.006) was established. In humans, standartized values of peak concentration and area under the concentration curve were significantly higher, specific volume of distribution and total clearance were lower, and half-life and mean retention time were significantly higher than in dogs. Characteristics of apparent bioavailability in dogs and healthy people did not statistically differ.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Amitriptyline / blood*
  • Amitriptyline / pharmacokinetics*
  • Animals
  • Antidepressive Agents / blood*
  • Antidepressive Agents / pharmacokinetics*
  • Area Under Curve
  • Dogs
  • Female
  • Half-Life
  • Humans
  • Linear Models
  • Male
  • Species Specificity
  • Young Adult


  • Antidepressive Agents
  • Amitriptyline