Beating Poisson encapsulation statistics using close-packed ordering

Lab Chip. 2009 Sep 21;9(18):2628-31. doi: 10.1039/b909386a. Epub 2009 Jul 28.


Loading drops with discrete objects, such as particles and cells, is often necessary when performing chemical and biological assays in microfluidic devices. However, random loading techniques are inefficient, yielding a majority of empty and unusable drops. We use deformable particles that are close packed to insert a controllable number of particles into every drop. This provides a simple, flexible means of efficiently encapsulating a controllable number of particles per drop.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Data Interpretation, Statistical*
  • Drug Compounding
  • Microfluidic Analytical Techniques
  • Microfluidics / statistics & numerical data*
  • Nanoparticles
  • Poisson Distribution*