Serum IL-6 level may have role in the pathophysiology of unexplained infertility

Am J Reprod Immunol. 2009 Oct;62(4):261-7. doi: 10.1111/j.1600-0897.2009.00734.x. Epub 2009 Aug 24.


Problem: The aim of this study was to compare the serum levels of interleukin (IL)-6 of women with unexplained infertility with fertile subjects.

Method of study: Serum IL-6, and tumor necrosis factor-alpha (TNF-alpha) levels of 45 infertile and 44 fertile women on day 3 of menstrual cycle were assessed and compared for this prospective controlled study.

Results: The mean serum IL-6 level was significantly higher in women with unexplained infertility, compared with fertile women (5.71 +/- 1.81 and 4.31 +/- 1.79, P < 0.001, Student's t-test). There was no significant difference in TNF-alpha level among the groups.

Conclusion: Significant difference in serum IL-6 levels between unexplained infertile and fertile women suggests that this cytokine may be involved in pathophysiology of unexplained infertility.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Age Factors
  • Body Mass Index
  • Female
  • Humans
  • Infertility, Female / blood*
  • Infertility, Female / diagnosis
  • Infertility, Female / immunology*
  • Infertility, Female / physiopathology
  • Interleukin-6 / blood*
  • Menstrual Cycle
  • Pregnancy
  • Prognosis
  • Prospective Studies
  • Tumor Necrosis Factor-alpha / blood*


  • Interleukin-6
  • Tumor Necrosis Factor-alpha