High prevalence of antimicrobial drug-resistant diarrheagenic Escherichia coli in asymptomatic children living in an urban slum

J Infect. 2009 Oct;59(4):247-51. doi: 10.1016/j.jinf.2009.08.007. Epub 2009 Aug 23.

Abstract

Purpose: The aim of this study was to investigate the presence of diarrheagenic Escherichia coli and antibiotic resistance in asymptomatic school-age children living in an area with defective environmental sanitation, comparing with children registered at a private school, both in the city of Osasco, Brazil.

Methods: Seventy-nine school-age children between 5 and 10 years living in a slum and 35 children who attended a private school of the same city were included in the study.

Results: DEC was found in 58% of the children living in the slum and in 17% of the control group (P=0.001). Resistance to at least one antimicrobial drug was found in 65% of DEC strains; resistant to two or more antimicrobial drugs was found in 46% of strains.

Conclusion: The high carriage status among the slum children point towards the widespread environment contamination in low socio-economic housing conditions, in conformance with the pediatric population at higher risk for developing DEC diarrhea.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Brazil / epidemiology
  • Child
  • Child, Preschool
  • Cities
  • Diarrhea / epidemiology*
  • Drug Resistance, Bacterial*
  • Escherichia coli / isolation & purification*
  • Escherichia coli Infections / epidemiology*
  • Feces / microbiology
  • Female
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Population
  • Poverty Areas*
  • Prevalence
  • Virulence Factors / analysis

Substances

  • Anti-Bacterial Agents
  • Virulence Factors