Psychotogenic drug use and neuroleptic response

Schizophr Bull. 1990;16(1):81-5. doi: 10.1093/schbul/16.1.81.


When fixed doses of haloperidol or perphenazine were used in two separate studies, we found that psychotic males with a prior history of psychotogenic drug use had a poorer early neuroleptic response even in the early stages of their psychotic disorder than psychotic males who had not previously used significant amounts of psychotogenic drugs. Relative neuroleptic refractoriness may be characteristic of some dual diagnosis patients at the beginning of their illness. Antecedent psychotogenic drug use may contribute to the development of psychosis and to relative neuroleptic refractoriness by means of effects upon dopaminergic mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Antipsychotic Agents / therapeutic use*
  • Bipolar Disorder / complications
  • Depressive Disorder / complications
  • Haloperidol / therapeutic use
  • Homovanillic Acid / blood
  • Humans
  • Male
  • Methoxyhydroxyphenylglycol / blood
  • Perphenazine / therapeutic use
  • Psychiatric Status Rating Scales
  • Psychotic Disorders / complications
  • Psychotropic Drugs*
  • Schizophrenia / blood
  • Schizophrenia / complications*
  • Schizophrenia / drug therapy
  • Schizophrenic Psychology*
  • Substance-Related Disorders / complications*


  • Antipsychotic Agents
  • Psychotropic Drugs
  • Methoxyhydroxyphenylglycol
  • Perphenazine
  • Haloperidol
  • Homovanillic Acid