TTMPP: An Efficient Organocatalyst in the Ring-Opening of Aziridines With Silylated Nucleophiles

Org Biomol Chem. 2009 Sep 21;7(18):3792-6. doi: 10.1039/b908322g. Epub 2009 Jul 16.

Abstract

The ring-opening of N-tosylaziridines with silylated nucleophiles catalyzed by tris(2,4,6-trimethoxyphenyl)phosphine (TTMPP) afforded the corresponding beta-functionalized sulfonamides in excellent yield under mild reaction conditions.

MeSH terms

  • Aziridines / chemistry*
  • Catalysis
  • Cyanides / chemistry
  • Organosilicon Compounds / chemistry*
  • Phosphines / chemistry*
  • Trimethylsilyl Compounds / chemistry

Substances

  • Aziridines
  • Cyanides
  • Organosilicon Compounds
  • Phosphines
  • Trimethylsilyl Compounds
  • tris(2,4,6-trimethoxyphenyl)phosphine
  • aziridine
  • trimethylsilyl cyanide