A five-patient satisfaction pilot study of calcium hydroxylapatite injection for treatment of aging hands

Dermatol Surg. 2009 Dec;35(12):1978-84. doi: 10.1111/j.1524-4725.2009.01312.x.


Background: The process of skin aging is not limited to the face but involves every part of the body, including the hands. A common manifestation of aging of the hands is the loss of volume, which occurs as the skin loses its subcutaneous fat. Injectable dermal fillers have surfaced as a popular method to address such deficiencies.

Objectives: To report the use of calcium hydroxylapatite (CaHA) to address lost volume.

Methods: Five female subjects with soft tissue deficiency of the dorsa of the hands were enrolled at Mount Sinai Medical Center. A solution of CaHA with 2% lidocaine in amounts of 0.3 to 1.0 mL was injected interdigitally at each of three to five insertion sites; the sites were massaged and molded up to three times to ensure an optimal cosmetic end point. Subjects were seen for a follow-up visit after 1, 4, 16, and 24 weeks.

Results: With a single injection, all subjects reached their correction goals without requiring any touch-ups. At the 24-week visit, the subjects retained the filling effect, with no adverse events and high patient satisfaction.

Conclusion: CaHA, a new, easily injectable, safe dermal filler, has emerged as an excellent option for soft tissue augmentation in aging hands.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Biocompatible Materials / administration & dosage*
  • Cosmetic Techniques
  • Durapatite / administration & dosage*
  • Female
  • Hand
  • Humans
  • Injections
  • Middle Aged
  • Patient Satisfaction
  • Pilot Projects
  • Skin Aging*


  • Biocompatible Materials
  • Durapatite