Radiographic repair in three Japanese patients with rheumatoid arthritis treated with bucillamine

Yuki Nanke; Masako Iwatani; Tsuyoshi Kobashigawa; Toru Yago; Hisashi Yamanaka; Shigeru Kotake

doi:10.1007/s10165-009-0209-6

Radiographic repair in three Japanese patients with rheumatoid arthritis treated with bucillamine

Mod Rheumatol. 2009;19(6):681-6. doi: 10.1007/s10165-009-0209-6. Epub 2009 Aug 27.

Authors

Yuki Nanke¹, Masako Iwatani, Tsuyoshi Kobashigawa, Toru Yago, Hisashi Yamanaka, Shigeru Kotake

Affiliation

¹ Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo, 162-0054, Japan. ynn@ior.twmu.ac.jp

PMID: 19711150
DOI: 10.1007/s10165-009-0209-6

Abstract

Bucillamine (Bc) is a cysteine derivative with two SH groups, and a homolog of D-penicillamine, a disease-modifying antirheumatic drug (DMARD) widely used in Japan. However, it remains unclear whether Bc repairs bone erosion in patients with RA. Here, we treated three RA patients with Bc who subsequently showed radiographic repair of erosions and cysts.

Publication types

Case Reports

MeSH terms

Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Arthritis, Rheumatoid / diagnostic imaging*
Arthritis, Rheumatoid / drug therapy*
Arthritis, Rheumatoid / pathology
Arthrography
Bone and Bones / diagnostic imaging*
Bone and Bones / pathology*
Cysteine / analogs & derivatives*
Cysteine / therapeutic use
Disease Progression
Female
Humans
Joints / pathology
Male
Middle Aged
Recovery of Function
Severity of Illness Index
Treatment Outcome

Substances

Anti-Inflammatory Agents, Non-Steroidal
Cysteine
bucillamine