A sample of 112 Asian-Indian Immigrant grandchildren, age 10-16 years, from different parts of the United States completed survey questionnaires regarding the quality of relationship with their grandparents in India. The study explored the factors that affected the quality of relationship between two different generations living at considerable geographical distance and in different cultures. Findings indicated that role importance, amount of contact, and health of the grandparent uniquely contributed to the relationship quality. Results also indicated acculturation was not a significant predictor of relationship quality, although it was a significant predictor of role importance. Limitations to the study relative to acculturation scores and sampling are discussed and further research should address these limitations and the grandparent-parent relationship. Implications include adopting a tri-generational perspective in future studies and practice.