Squamous cell cancer is a very rare malignancy in colon and rectum. It accounts for 0.05-0.1% of all types of cancers in this localization. It predominantly occurs in caecum. In the article we present a case of 77 year old women who was operated due to tumor of caecum which infiltrated the proximal transverse colon. During the operation a right hemicolectomy was performed. There were no macroscopic signs of metastases in liver and lymph nodes. Histopathological examination of removed tumor revealed squamous cell carcinoma of caecum in pT4 stage. In the Clinic retrospective material squamous cell cancer of colon accounts for 0.07% of the total colon cancer cases. The patient was disqualified from post-operative chemotherapy because of the age and general condition. Four months after the operation liver metastases and ascites occurred. The patient died five months after the surgery. Despite the radical surgical treatment the course of the disease was rapid.