Genes encoding the beta-chains of HLA-DR7 and HLA-DQw2 define major susceptibility determinants for idiopathic nephrotic syndrome

Clin Sci (Lond). 1990 Apr;78(4):391-7. doi: 10.1042/cs0780391.


1. We have investigated the frequencies of the major histocompatibility complex class II alleles by restriction fragment length polymorphism analysis, using DR, DQ and DP complementary DNA probes, in 40 Caucasoid steroid-sensitive nephrotic children. 2. A significant association with HLA-DR7 was demonstrated (P = 2 x 10(-5); aetiological fraction 0.6). The DQB1 gene of HLA-DQw2 was present in 83% of our patients (P = 2 x 10(-4); aetiological fraction 0.7). We present evidence that it contributes a second susceptibility allele. 3. A weak association between the uncommon HLA-DP-Cp63 allele and the disease was also observed. 4. Our data suggest that the immune events in steroid-sensitive nephrotic syndrome are defined by a particular immunogenetic background involving the beta-chain genes of HLA-DR7 and HLA-DQw2.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Alleles
  • Child
  • Child, Preschool
  • DNA Probes
  • Disease Susceptibility
  • Female
  • Gene Frequency
  • HLA-DQ Antigens / genetics*
  • HLA-DR7 Antigen / genetics*
  • Humans
  • Infant
  • Male
  • Nephrosis, Lipoid / genetics*
  • Phenotype
  • Polymorphism, Restriction Fragment Length


  • DNA Probes
  • HLA-DQ Antigens
  • HLA-DQ2 antigen
  • HLA-DR7 Antigen