Genes encoding the beta-chains of HLA-DR7 and HLA-DQw2 define major susceptibility determinants for idiopathic nephrotic syndrome

Clin Sci (Lond). 1990 Apr;78(4):391-7. doi: 10.1042/cs0780391.

Abstract

1. We have investigated the frequencies of the major histocompatibility complex class II alleles by restriction fragment length polymorphism analysis, using DR, DQ and DP complementary DNA probes, in 40 Caucasoid steroid-sensitive nephrotic children. 2. A significant association with HLA-DR7 was demonstrated (P = 2 x 10(-5); aetiological fraction 0.6). The DQB1 gene of HLA-DQw2 was present in 83% of our patients (P = 2 x 10(-4); aetiological fraction 0.7). We present evidence that it contributes a second susceptibility allele. 3. A weak association between the uncommon HLA-DP-Cp63 allele and the disease was also observed. 4. Our data suggest that the immune events in steroid-sensitive nephrotic syndrome are defined by a particular immunogenetic background involving the beta-chain genes of HLA-DR7 and HLA-DQw2.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Alleles
  • Child
  • Child, Preschool
  • DNA Probes
  • Disease Susceptibility
  • Female
  • Gene Frequency
  • HLA-DQ Antigens / genetics*
  • HLA-DR7 Antigen / genetics*
  • Humans
  • Infant
  • Male
  • Nephrosis, Lipoid / genetics*
  • Phenotype
  • Polymorphism, Restriction Fragment Length

Substances

  • DNA Probes
  • HLA-DQ Antigens
  • HLA-DQ2 antigen
  • HLA-DR7 Antigen