Treatment of recurrent miscarriage and antiphospholipid syndrome with low-dose enoxaparin and aspirin

Reprod Biomed Online. 2009 Aug;19(2):216-20. doi: 10.1016/s1472-6483(10)60075-2.


The aim of this retrospective, observational study was to determine the impact of low-dose enoxaparin (20 mg) in conjunction with low-dose aspirin on the pregnancy outcome of women with antiphospholipid syndrome and recurrent miscarriage. The study was conducted in a tertiary referral teaching hospital. A total of 35 women with antiphospholipid syndrome were treated with low-dose enoxaparin and aspirin as soon as pregnancy was confirmed. The outcome of pregnancy was analysed. The miscarriage rate was 7/35 (20%) whereas the live birth rate was 28/35 (80%). In conclusion, low-dose (20 mg) enoxaparin in conjunction with low-dose aspirin treatment produced encouraging results. The findings in this study suggest that there is a case for randomized controlled trials to compare low-dose (20 mg) enoxaparin with higher doses.

MeSH terms

  • Abortion, Habitual*
  • Adult
  • Anticoagulants / administration & dosage
  • Anticoagulants / therapeutic use*
  • Antiphospholipid Syndrome / drug therapy*
  • Antiphospholipid Syndrome / physiopathology
  • Aspirin / administration & dosage
  • Aspirin / therapeutic use*
  • Dose-Response Relationship, Drug
  • Drug Therapy, Combination
  • Enoxaparin / administration & dosage
  • Enoxaparin / therapeutic use*
  • Female
  • Humans
  • Pregnancy
  • Pregnancy Complications / drug therapy*
  • Retrospective Studies


  • Anticoagulants
  • Enoxaparin
  • Aspirin