[Acute toxicity of high doses of methotrexate in treatment of ALL in children: a case study]

Farm Hosp. 2009 May-Jun;33(3):172-3. doi: 10.1016/s1130-6343(09)71159-6.
[Article in Spanish]
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Acute Disease
  • Acute Kidney Injury / chemically induced*
  • Acute Kidney Injury / drug therapy
  • Antimetabolites, Antineoplastic / administration & dosage
  • Antimetabolites, Antineoplastic / adverse effects*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Chemical and Drug Induced Liver Injury / etiology*
  • Child
  • Fever / chemically induced*
  • Fever / drug therapy
  • Folic Acid Antagonists / administration & dosage
  • Folic Acid Antagonists / adverse effects*
  • Furosemide / therapeutic use
  • Genetic Predisposition to Disease
  • Heterozygote
  • Humans
  • Leucovorin / therapeutic use
  • Leukemia, B-Cell / drug therapy*
  • Male
  • Methotrexate / administration & dosage
  • Methotrexate / adverse effects*
  • Methylenetetrahydrofolate Reductase (NADPH2) / genetics
  • Mutation, Missense
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
  • gamma-Glutamyl Hydrolase / therapeutic use

Substances

  • Antimetabolites, Antineoplastic
  • Folic Acid Antagonists
  • Furosemide
  • Methylenetetrahydrofolate Reductase (NADPH2)
  • gamma-Glutamyl Hydrolase
  • Leucovorin
  • Methotrexate