Body weight change in women receiving adjuvant chemotherapy for breast cancer: a French prospective study

Clin Nutr. 2010 Apr;29(2):187-91. doi: 10.1016/j.clnu.2009.08.003. Epub 2009 Aug 26.


Background & aims: Adjuvant chemotherapy has frequently been associated with weight gain after breast cancer diagnosis. We aimed to prospectively evaluate body weight variations in French patients with early breast cancer.

Methods: This prospective observational study included 272 breast cancer patients who were candidates for adjuvant chemotherapy. Weight and body mass index were measured at baseline visit, then at 9 and 15 months from baseline (6 and 12-month post-chemotherapy). At baseline visit, information on the benefits of weight gain prevention and healthy diet was given by a dietician. Univariate logistic regression was performed to test the association between weight gain and potential predictive factors.

Results: Thirty percent of patients gained weight during the year before diagnosis, 26% were overweight and 15% were obese. At one year, the mean weight change was +1.5kg (SD=4.1) and +2.3% (SD=6.0); 60% of the cohort had gained weight, with a median increase of 3.9kg (SD=3.0) and 5.9% (SD=4.4). Reported weight gain during the year before diagnosis appears to be the only factor associated with the absence of post-chemotherapy weight gain (OR=0.54, 95% CI [0.31-0.95], p=0.034).

Conclusion: Body weight increased in the post-chemotherapy period in French breast cancer survivors, even when given dietary recommendations. Appropriate weight management interventions with nutritional follow-up and physical activity programs are needed.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Aging
  • Anthropometry
  • Body Mass Index
  • Body Weight* / drug effects
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / pathology
  • Breast Neoplasms / surgery
  • Carcinoma / drug therapy*
  • Carcinoma / pathology
  • Carcinoma / surgery
  • Chemotherapy, Adjuvant
  • Cohort Studies
  • Diet
  • Early Detection of Cancer
  • Female
  • Follow-Up Studies
  • France
  • Humans
  • Middle Aged
  • Neoplasm Invasiveness
  • Patient Education as Topic
  • Postmenopause
  • Premenopause
  • Prospective Studies
  • Time Factors
  • Young Adult