Abstract
The role of 5-HT1A autoreceptors in the discriminative stimulus properties of 8-OH-DPAT (0.1 mg/kg, SC) in rats, was investigated. Drug lever appropriate responding to 8-OH-DPAT (0.1 mg/kg, SC) and ipsapirone (3 mg/kg, SC) was measured before and after treatment with para-chlorophenylalanine (pCPA) at a dose (150 mg/kg IP, -3 and -2 days) which causes severe depletion of brain 5-HT stores. The recognition of the drug stimulus was not significantly altered by pCPA. These results indicate that activation of 5-HT1A autoreceptors is of minimal importance to the 8-OH-DPAT cue.
MeSH terms
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8-Hydroxy-2-(di-n-propylamino)tetralin
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Animals
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Brain Chemistry / drug effects
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Discrimination, Psychological / drug effects*
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Dose-Response Relationship, Drug
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Fenclonine / antagonists & inhibitors
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Fenclonine / pharmacology*
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Generalization, Psychological / drug effects
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Male
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Naphthalenes / pharmacology*
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Neurotransmitter Agents / metabolism
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Pyrimidines / pharmacology
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Rats
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Rats, Inbred Strains
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Tetrahydronaphthalenes / pharmacology*
Substances
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Naphthalenes
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Neurotransmitter Agents
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Pyrimidines
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Tetrahydronaphthalenes
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ipsapirone
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8-Hydroxy-2-(di-n-propylamino)tetralin
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Fenclonine