Concomitant Aspergillus and Cytomegalovirus infection in heart transplant: early diagnosis is the key to successful treatment

Exp Clin Transplant. 2009 Sep;7(3):168-72.

Abstract

Concomitant infections, which are common in patients who have received an organ transplant, must be diagnosed and treated early to prevent high mortality rates. We describe a case of concomitant Cytomegalovirus infection and Aspergillus pneumonia in a heart transplant patient who received pulsed steroids as therapy for rejection, and we describe the successful treatment of that coinfection with ganciclovir and voriconazole.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Antifungal Agents / therapeutic use*
  • Antiviral Agents / therapeutic use*
  • Cardiomyopathy, Dilated / surgery
  • Cytomegalovirus Infections / diagnosis*
  • Cytomegalovirus Infections / drug therapy
  • Cytomegalovirus Infections / virology
  • Early Diagnosis
  • Ganciclovir / therapeutic use
  • Graft Rejection / drug therapy*
  • Graft Rejection / immunology
  • Heart Transplantation / adverse effects*
  • Humans
  • Immunosuppressive Agents / administration & dosage
  • Immunosuppressive Agents / adverse effects*
  • Invasive Pulmonary Aspergillosis / diagnosis*
  • Invasive Pulmonary Aspergillosis / drug therapy
  • Invasive Pulmonary Aspergillosis / microbiology
  • Male
  • Middle Aged
  • Opportunistic Infections / diagnosis*
  • Opportunistic Infections / drug therapy
  • Opportunistic Infections / microbiology
  • Opportunistic Infections / virology
  • Pulse Therapy, Drug
  • Pyrimidines / therapeutic use
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Triazoles / therapeutic use
  • Voriconazole

Substances

  • Antifungal Agents
  • Antiviral Agents
  • Immunosuppressive Agents
  • Pyrimidines
  • Triazoles
  • Voriconazole
  • Ganciclovir