Unraveling the secrets of regulating mitochondrial DNA replication

Mol Cell. 2009 Aug 28;35(4):398-400. doi: 10.1016/j.molcel.2009.08.007.

Abstract

In this issue, Liu et al. (2009) report that maxicircle DNA copy number in trypanosomes is regulated by proteolysis of a helicase; the complex kinetoplast DNA system yields a clear view of how mitochondrial DNA replication can be regulated.

Publication types

  • Comment

MeSH terms

  • Animals
  • DNA Helicases / genetics
  • DNA Helicases / metabolism*
  • DNA Replication*
  • DNA, Kinetoplast / biosynthesis*
  • DNA, Mitochondrial / biosynthesis*
  • DNA, Protozoan / biosynthesis*
  • Gene Expression Regulation
  • Mutation
  • Peptide Hydrolases / metabolism
  • Protozoan Proteins / genetics
  • Protozoan Proteins / metabolism*
  • Time Factors
  • Trypanosoma brucei brucei / enzymology
  • Trypanosoma brucei brucei / genetics*
  • Trypanosoma brucei brucei / growth & development

Substances

  • DNA, Kinetoplast
  • DNA, Mitochondrial
  • DNA, Protozoan
  • Protozoan Proteins
  • Peptide Hydrolases
  • DNA Helicases