Electronic screening improves efficiency in clinical trial recruitment

J Am Med Inform Assoc. Nov-Dec 2009;16(6):869-73. doi: 10.1197/jamia.M3119. Epub 2009 Aug 28.

Abstract

This study evaluated the performance of an electronic screening (E-screening) method and used it to recruit patients for the NIH sponsored ACCORD trial. Out of the 193 E-screened patients, 125 met the age criterion ("age>or=40"). For all of these 125 patients, the performance of E-screening was compared with investigator review. E-screening achieved a negative predictive accuracy of 100% (95% CI: 98-100%), a positive predictive accuracy of 13% (95% CI: 6-13%), a sensitivity of 100% (95% CI: 45-100%), and a specificity of 84% (95% CI: 82-84%). The method maximized the use of a patient database query (i.e., excluded ineligible patients with a 100% accuracy and automatically assembled patient information to facilitate manual review of only patients who were classified as "potentially eligible" by E-screening) and significantly reduced the screening burden associated with the ACCORD trial.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Data Mining
  • Diabetes Mellitus, Type 2
  • Eligibility Determination*
  • Humans
  • Information Storage and Retrieval*
  • Medical Records Systems, Computerized*
  • New York City
  • Patient Selection*
  • Predictive Value of Tests
  • Sensitivity and Specificity
  • Workflow