IL-21 is critical for GVHD in a mouse model

Bone Marrow Transplant. 2010 Apr;45(4):723-9. doi: 10.1038/bmt.2009.223. Epub 2009 Aug 31.


Immunological effects of IL-21 on T, B and natural killer (NK) cells have been reported, but the role of IL-21 in GVHD remains obscure. Here, we demonstrate that morbidity and mortality of GVHD was significantly reduced after BMT with splenocytes from IL-21R(-/-) mice compared with those from wild type mice. To further confirm our observation, we generated a decoy receptor for IL-21. GVHD was again less severe in mice receiving BM cells transduced with the IL-21 decoy receptor than control mice These results suggest that IL-21 critically regulates GVHD, and that blockade of the IL-21 signal may represent a novel strategy for the prophylaxis for GVHD.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Marrow Transplantation / adverse effects*
  • CD4-CD8 Ratio
  • Disease Models, Animal*
  • Graft vs Host Disease / immunology*
  • Interleukins / immunology*
  • Kaplan-Meier Estimate
  • Mice
  • Mice, Inbred BALB C
  • Mice, Knockout


  • Interleukins
  • interleukin-21