The effect of oxcarbazepine on bone metabolism

Acta Neurol Scand. 2009 Sep;120(3):170-5. doi: 10.1111/j.1600-0404.2008.01148.x.


Objective: Long term use of several antiepileptic drugs is known to cause alteration in bone metabolism. Therefore, we investigated the effect of new antiepileptic drug, oxcarbazepine, on bone metabolism.

Methods: Twenty eight patients who were on oxcarbazepin therapy (18 female, 10 males; mean age: 27.82 +/- 10.98 years (range: 15-45)) with no additional antiepileptic drug use history in one year period prior to the study and 28 control subjects were involved in the study. Measurement of calcium, phosphate, alkaline phosphatase and Vitamin D3 levels and bone density measurements with DEXA method were performed in patient and age-matched control groups. The baseline parameters were compared with the control group and with those measured at the end of one year.

Results: The biochemical (calcium, phosphate, alkaline phosphatase and Vitamin D3) parameters and densitometry values after one year of therapy were not different than the baseline values indicating that those were not affected by the therapy (P > 0.05).

Conclusions: In previous studies, anticonvulsant drugs that induce enzymes increase bone degradation by causing vitamin D deficiency. According to the results of this study, oxcarbazepin with little effect on enzyme induction was shown not to affect bone mineral metabolism.

MeSH terms

  • Absorptiometry, Photon
  • Adolescent
  • Adult
  • Alkaline Phosphatase / metabolism
  • Anticonvulsants / adverse effects
  • Bone Density
  • Bone Diseases, Metabolic / chemically induced*
  • Bone Diseases, Metabolic / diagnostic imaging
  • Bone Diseases, Metabolic / metabolism
  • Bone and Bones / diagnostic imaging
  • Bone and Bones / metabolism*
  • Calcium / metabolism
  • Carbamazepine / adverse effects
  • Carbamazepine / analogs & derivatives*
  • Cholecalciferol / metabolism
  • Female
  • Humans
  • Male
  • Middle Aged
  • Oxcarbazepine
  • Phosphates / metabolism


  • Anticonvulsants
  • Phosphates
  • Cholecalciferol
  • Carbamazepine
  • Alkaline Phosphatase
  • Calcium
  • Oxcarbazepine