Abstract
Paraspeckles are ribonucleoprotein bodies found in the interchromatin space of mammalian cell nuclei. These structures play a role in regulating the expression of certain genes in differentiated cells by nuclear retention of RNA. The core paraspeckle proteins (PSF/SFPQ, P54NRB/NONO, and PSPC1 [paraspeckle protein 1]) are members of the DBHS (Drosophila melanogaster behavior, human splicing) family. These proteins, together with the long nonprotein-coding RNA NEAT1 (MEN-epsilon/beta), associate to form paraspeckles and maintain their integrity. Given the large numbers of long noncoding transcripts currently being discovered through whole transcriptome analysis, paraspeckles may be a paradigm for a class of subnuclear bodies formed around long noncoding RNA.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Nucleus / metabolism
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Cell Nucleus / ultrastructure
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DNA-Binding Proteins
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Gene Expression Regulation
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Humans
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Intranuclear Inclusion Bodies / genetics*
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Intranuclear Inclusion Bodies / metabolism
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Nuclear Matrix-Associated Proteins / genetics
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Nuclear Matrix-Associated Proteins / metabolism
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism
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Octamer Transcription Factors / genetics
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Octamer Transcription Factors / metabolism
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PTB-Associated Splicing Factor
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RNA, Untranslated / genetics
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RNA, Untranslated / metabolism*
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RNA-Binding Proteins / genetics
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RNA-Binding Proteins / metabolism
Substances
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DNA-Binding Proteins
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NONO protein, human
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Nuclear Matrix-Associated Proteins
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Nuclear Proteins
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Octamer Transcription Factors
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PSPC1 protein, human
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PTB-Associated Splicing Factor
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RNA, Untranslated
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RNA-Binding Proteins