Abstract
Transposon inactivation of ycgE, a gene encoding a putative transcriptional regulator, led to decreased multidrug susceptibility in an Escherichia coli lon mutant. The multidrug susceptibility phenotype (e.g., to tetracycline and beta-lactam antibiotics) required the inactivation of both lon and ycgE. In this mutant, a decreased amount of OmpF porin contributes to the lowered drug susceptibility, with a greater effect at 26 degrees C than at 37 degrees C.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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DNA-Binding Proteins / physiology
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Drug Resistance, Multiple, Bacterial
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Escherichia coli / drug effects*
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Escherichia coli / genetics
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Escherichia coli Proteins / physiology*
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Lipoproteins / physiology
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Membrane Transport Proteins / physiology
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Microbial Sensitivity Tests
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Multidrug Resistance-Associated Proteins / physiology
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Porins / physiology*
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Protease La / physiology*
Substances
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AcrA protein, E coli
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AcrB protein, E coli
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DNA-Binding Proteins
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Escherichia coli Proteins
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Lipoproteins
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MarA protein, E coli
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Membrane Transport Proteins
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Multidrug Resistance-Associated Proteins
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OmpF protein
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Porins
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Lon protein, E coli
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Protease La