[Incretin and bone]

Clin Calcium. 2009 Sep;19(9):1312-7.
[Article in Japanese]

Abstract

Gastrointestinal hormones including gastric inhibitory polypeptide (GIP) and glucagon-like peptide (GLP) -1 are incretin, which are secreted immediately after meal ingestion and stimulate insulin secretion from pancreatic beta-cells. Characterization of extra-pancreatic GIP and GLP-1 receptors has revealed that these hormones regulate bone turnover. GIP intermittently stimulates osteoblasts and GLP-1 suppresses osteoclasts through a calcitonin-dependent pathway to increase the bone volume.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone and Bones / metabolism*
  • Calcitonin / physiology
  • Eating / physiology
  • Gastric Inhibitory Polypeptide / metabolism
  • Gastric Inhibitory Polypeptide / physiology
  • Glucagon-Like Peptide 1 / metabolism
  • Glucagon-Like Peptide 1 / physiology
  • Glucagon-Like Peptide-1 Receptor
  • Humans
  • Incretins / metabolism
  • Incretins / physiology*
  • Insulin / metabolism
  • Insulin Secretion
  • Insulin-Secreting Cells / metabolism
  • Osteoblasts / physiology
  • Osteoclasts / physiology
  • Receptors, Gastrointestinal Hormone / physiology
  • Receptors, Glucagon / physiology

Substances

  • GLP1R protein, human
  • Glucagon-Like Peptide-1 Receptor
  • Incretins
  • Insulin
  • Receptors, Gastrointestinal Hormone
  • Receptors, Glucagon
  • Gastric Inhibitory Polypeptide
  • Glucagon-Like Peptide 1
  • Calcitonin
  • gastric inhibitory polypeptide receptor