Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of research

An Acad Bras Cienc. 2009 Sep;81(3):521-38. doi: 10.1590/s0001-37652009000300016.


Sleep comprises approximately one-third of a person's lifetime, but its impact on health and medical conditions remains partially unrecognized. The prevalence of sleep disorders is increasing in modern societies, with significant repercussions on people's well-being. This article reviews past and current literature on the paradoxical sleep deprivation method as well as data on its consequences to animals, ranging from behavioral changes to alterations in the gene expression. More specifically, we highlight relevant experimental studies and our group's contribution over the last three decades.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Behavior, Animal / physiology*
  • Brain Chemistry / physiology
  • Depression / etiology*
  • Depression / physiopathology
  • Disease Models, Animal
  • Gene Expression
  • Neurotransmitter Agents / metabolism*
  • Oxidative Stress / physiology
  • Sleep Deprivation / complications
  • Sleep Deprivation / metabolism*
  • Sleep Deprivation / physiopathology
  • Stress, Psychological / etiology*
  • Stress, Psychological / physiopathology


  • Neurotransmitter Agents