Kava-induced dermopathy: a niacin deficiency?

Lancet. 1990 Jun 16;335(8703):1442-5. doi: 10.1016/0140-6736(90)91458-m.


Heavy chronic consumption of kava (Piper methysticum) is associated with a pellagroid dermopathy that has been attributed to niacin deficiency. Over 200 male kava drinkers in the Tonga Islands were interviewed and examined regarding the characteristic skin changes. A scaly rash suggestive of ichthyosis and eye irritation were present in some heavy kava drinkers. 29 kava drinkers with prominent skin changes were randomised to receive either 100 mg oral nicotinamide or placebo daily for three weeks. Skin examinations and photographs showed clinical improvement in 5/15 of the nicotinamide group and 5/14 of the placebo group. These data, along with history and physical examination findings, suggest that niacin deficiency is not responsible for the rash, which is more characteristic of an acquired ichthyosis.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adult
  • Aged
  • Cultural Characteristics
  • Double-Blind Method
  • Drug Evaluation
  • Humans
  • Ichthyosis / chemically induced*
  • Ichthyosis / drug therapy
  • Ichthyosis / epidemiology
  • Ichthyosis / pathology
  • Male
  • Middle Aged
  • Niacin / deficiency*
  • Niacinamide / administration & dosage
  • Niacinamide / therapeutic use
  • Patient Compliance
  • Plant Extracts / adverse effects*
  • Prospective Studies
  • Randomized Controlled Trials as Topic
  • Severity of Illness Index
  • Time Factors
  • Tonga / epidemiology


  • Plant Extracts
  • Niacinamide
  • Niacin