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. 2009;10(9):238.
doi: 10.1186/gb-2009-10-9-238. Epub 2009 Sep 2.

Predicting Drug Side-Effects by Chemical Systems Biology

Free PMC article

Predicting Drug Side-Effects by Chemical Systems Biology

Nicholas P Tatonetti et al. Genome Biol. .
Free PMC article


New approaches to predicting ligand similarity and protein interactions can explain unexpected observations of drug inefficacy or side-effects.


Figure 1
Figure 1
Meta-networks allow novel inferences. Systems approaches allow the generation of networks of genes based on common pathways or common evolutionary history, networks of drugs based on chemical similarity or similarity in biological effects, and networks of effects based on similar biological pathways and cellular compartments. The ability to link these three networks allows novel inferences.

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