Bacteremia With a Large Clostridial Toxin-Negative, Binary Toxin-Positive Strain of Clostridium Difficile

Anaerobe. 2009 Dec;15(6):249-51. doi: 10.1016/j.anaerobe.2009.08.006. Epub 2009 Aug 31.

Abstract

Bacteremia caused by Clostridium difficile is rare. In this report, we describe a case of C. difficile bacteremia caused by an unusual strain of C. difficile. The isolate contained neither toxin A nor B genes, however, binary toxin genes were present (tcdA(-), tcdB(-), cdtA(+), cdtB(+)) and a 7.2-kb element unrelated to the PaLoc was found inserted within the PaLoc integration site. The clinical relevance of the isolate could not be determined.

Publication types

  • Case Reports

MeSH terms

  • ADP Ribose Transferases* / genetics
  • ADP Ribose Transferases* / metabolism
  • Adult
  • Bacteremia / diagnosis*
  • Bacteremia / microbiology*
  • Bacterial Proteins* / genetics
  • Bacterial Proteins* / metabolism
  • Bacterial Toxins* / genetics
  • Bacterial Toxins* / metabolism
  • Clostridium difficile / classification
  • Clostridium difficile / genetics
  • Clostridium difficile / isolation & purification
  • Clostridium difficile / pathogenicity*
  • Enterocolitis, Pseudomembranous / microbiology
  • Enterotoxins / genetics
  • Enterotoxins / metabolism
  • Humans
  • Male

Substances

  • Bacterial Proteins
  • Bacterial Toxins
  • Enterotoxins
  • tcdA protein, Clostridium difficile
  • toxB protein, Clostridium difficile
  • ADP Ribose Transferases
  • actin-specific ADP-ribosyltransferase, Clostridium