The debate surrounding the need for reform in nursing education has been heard for well over a decade. Recently, deficiencies in the quality of patient care, as well as patient safety issues, have led to calls for change in health professions education by nursing organizations and the Institute of Medicine (IOM). The rationale and scope of any proposed curricular revision or changes in teaching practices must be firmly grounded in a comprehensive review of the literature and based on current research findings. This article synthesizes the recent literature related to curriculum reform and innovation in nursing education. Four themes were identified in the literature: incorporating safety and quality in nursing education, re-designing conceptual frameworks, strategies to address content laden curricula, and teaching using alternative pedagogies. Synthesis of the recent literature in the field will assist faculty who are beginning the curriculum evaluation and revision process in their own schools.