Gout. Hyperuricemia and cardiovascular disease: how strong is the evidence for a causal link?

Arthritis Res Ther. 2009;11(4):240. doi: 10.1186/ar2761. Epub 2009 Aug 19.


An association between high levels of serum urate and cardiovascular disease has been proposed for many decades. However, it was only recently that compelling basic science data, small clinical trials, and epidemiological studies have provided support to the idea of a true causal effect. In this review we present recently published data that study the association between hyperuricemia and selected cardiovascular diseases, with a final conclusion about the possibility of this association being causal.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / etiology*
  • Gout / complications*
  • Gout / epidemiology
  • Humans
  • Hyperuricemia / complications*
  • Hyperuricemia / epidemiology
  • Uric Acid / blood


  • Uric Acid