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, 145 (1), 136-9

T Lymphocyte Recognition of a Celiac Disease-Associated Cis- Or Trans-Encoded HLA-DQ Alpha/Beta-Heterodimer

Affiliations
  • PMID: 1972714

T Lymphocyte Recognition of a Celiac Disease-Associated Cis- Or Trans-Encoded HLA-DQ Alpha/Beta-Heterodimer

K E Lundin et al. J Immunol.

Erratum in

  • J Immunol 1990 Nov 1;145(9):3151

Abstract

The HLA-associated susceptibility to develop celiac disease may to a large extent be attributed to the combination of particular DQA1 and DQB1 genes, i.e., the DQA1*0501 and DBQB1*0201 alleles, located either in cis position (on the DR3DQw2 haplotype) or in trans position (DR5DQw7/DR7DQw2 heterozygous individuals). We report three alloreactive T lymphocyte clones that recognize an HLA-DQ alpha/beta heterodimer both when the DQA1*0501 and DQB1*0201 alleles are located in cis or in trans position. Thus, the celiac disease associated DQA1 and DQB1 genes encode a functionally expressed DQ alpha/beta heterodimer.

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