Formation of 12-lipoxygenase metabolites in rat cerebral cortical slices: stimulation by calcium ionophore, glutamate and N-methyl-D-aspartate

J Neural Transm Suppl. 1990:29:29-37. doi: 10.1007/978-3-7091-9050-0_4.

Abstract

The 12-lipoxygenase pathway of arachidonic acid metabolism in rat cerebral cortex slices is stimulated by exogenous arachidonic acid, Ca2+ ionophore A23187, phorbol ester, glutamate, N-methyl-D-aspartate (NMDA) but not by kainate and other neurotransmitters except norepinephrine. The 12-hydroxyeicosatetraenoic acid formed is the (S)-enantiomer. A specific role for 12-lipoxygenase metabolites in NMDA receptor activation and long term potentiation is proposed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
  • Arachidonate 12-Lipoxygenase / metabolism*
  • Arachidonate Lipoxygenases / metabolism*
  • Aspartic Acid / analogs & derivatives*
  • Aspartic Acid / pharmacology
  • Calcimycin / pharmacology*
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / enzymology*
  • Glutamates / pharmacology*
  • Glutamic Acid
  • Hydroxyeicosatetraenoic Acids / metabolism
  • In Vitro Techniques
  • N-Methylaspartate
  • Neurotransmitter Agents / pharmacology
  • Phorbol Esters / pharmacology*

Substances

  • Glutamates
  • Hydroxyeicosatetraenoic Acids
  • Neurotransmitter Agents
  • Phorbol Esters
  • Aspartic Acid
  • Calcimycin
  • Glutamic Acid
  • 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
  • N-Methylaspartate
  • Arachidonate Lipoxygenases
  • Arachidonate 12-Lipoxygenase