A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo

Nature. 1990 Jun 21;345(6277):686-92. doi: 10.1038/345686a0.


The murine oct-3 gene encodes a transcription factor containing a POU-specific domain and a homeodomain. In marked contrast to other homeodomain-encoding genes, oct-3 is expressed in the totipotent and pluripotent stem cells of the pregastrulation embryo and is down-regulated during differentiation to endoderm and mesoderm, suggesting that it has a role in early development. The oct-3 gene is also expressed in primordial germ cells and in the female germ line.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cell Differentiation
  • DNA-Binding Proteins / genetics*
  • Down-Regulation
  • Embryo, Mammalian / metabolism*
  • Embryo, Nonmammalian*
  • Endoderm / cytology
  • Gene Expression*
  • Genes, Homeobox*
  • Germ Cells / metabolism*
  • Mesoderm / cytology
  • Molecular Sequence Data
  • Nucleic Acid Hybridization
  • Octamer Transcription Factor-3
  • Oocytes / growth & development
  • Oocytes / metabolism
  • RNA, Messenger / analysis
  • RNA, Messenger / genetics
  • Stem Cells / metabolism*
  • Transcription Factors / genetics*


  • DNA-Binding Proteins
  • Octamer Transcription Factor-3
  • RNA, Messenger
  • Transcription Factors