Ultrasonographic diagnosis of fetal structural abnormalities in prenatal screening at 11-14 weeks

Diagn Interv Radiol. 2009 Sep;15(3):221-5.


Purpose: The aim of the study was to determine the detection rate of structural abnormalities at the 11-14 week ultrasound examination as a part of two-stage screening process in low-risk pregnancies.

Materials and methods: A total of 1085 consecutive low-risk pregnant women participated in screening by two-stage ultrasonography for the estimation of the sensitivity of the first and second trimester ultrasound scans in the detection of major anomalies as a part of routine screening.

Results: Of 1085 pregnancies, 21 (1.93%) fetuses had at least one major structural defect considered detectable by routine ultrasound screening; 14 (1.29%) were identified at early screening and an additional 5 (0.47%) at late screening. Two abnormalities were not detected prenatally, and data were obtained from the patients after delivery.

Conclusion: The majority of fetal structural abnormalities can be detected by sonographic screening at 11-14 weeks, but detailed fetal anatomic survey performed at 18-22 weeks should not be abandoned.

MeSH terms

  • Abortion, Induced
  • Chromosome Aberrations / embryology*
  • Female
  • Hernia, Umbilical / diagnostic imaging
  • Hernia, Umbilical / embryology
  • Holoprosencephaly / diagnostic imaging
  • Holoprosencephaly / embryology
  • Humans
  • Karyotyping
  • Predictive Value of Tests
  • Pregnancy
  • Pregnancy Trimester, Second
  • Pregnancy Trimester, Third
  • Retrospective Studies
  • Sensitivity and Specificity
  • Ultrasonography, Prenatal*