Effect of low saturated fat diet in early and late cases of multiple sclerosis

Lancet. 1990 Jul 7;336(8706):37-9. doi: 10.1016/0140-6736(90)91533-g.


144 multiple sclerosis patients took a low-fat diet for 34 years. For each of three categories of neurological disability (minimum, moderate, severe) patients who adhered to the prescribed diet (less than or equal to 20 g fat/day) showed significantly less deterioration and much lower death rates than did those who consumed more fat than prescribed (greater than 20 g fat/day). The greatest benefit was seen in those with minimum disability at the start of the trial; in this group, when those who died from non-MS diseases were excluded from the analysis, 95% survived and remained physically active.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living
  • Adult
  • Cause of Death
  • Dietary Fats / administration & dosage*
  • Dietary Fats, Unsaturated / administration & dosage
  • Evaluation Studies as Topic
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Multiple Sclerosis / diet therapy*
  • Multiple Sclerosis / mortality
  • Neurologic Examination
  • Patient Compliance
  • Severity of Illness Index
  • Time Factors


  • Dietary Fats
  • Dietary Fats, Unsaturated